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KMID : 1011420120170020241
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Journal of Korean Ophthalmic Optics Society
2012 Volume.17 No. 2 p.241 ~ p.247
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Associations of Metabolic Syndrome with Glaucoma in Korean -Based on the Korean National Health and Nutrition Examination Survey 2005, 2007-9, 2010
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Park Sang-Shin
Kim Tae-Hun
Park Yun-Suk
Lee Sang-Yoon
Lee Hae-Jung
Lee Eun-Hee
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Abstract
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Purpose: This study was conducted to assess the association of metabolic syndrome and its components with
glaucoma.
Methods: We investigated the associations of metabolic syndrome and its components (abdominal obesity, impaired fasting glucose, high blood pressure, and dyslipidemia) with glaucoma using data from 19,162 adults aged 40 or above among the Korean National Health and Nutrition Examination Survey III (2005), IV (2007-9), V (2010). The logistic regression analysis was used for assessing those associations after adjusting demographic, lifestyle, and social economic status and for assessing the association of metabolic medication intakes with glaucoma risks.
Results: After adjusting for age and sex, the risk of glaucoma was significantly higher in the subjects with impaired fasting glucose(Odds Ratio (95% confidence interval): 1.78 (1.25, 2.53)) and metabolic syndrome (1.45 (1.01, 2.08)) than subjects without those. These associations increased when additional adjusting for smoking, alcohol use, regular physical activity, income, education status(impaired fasting glucose: 1.89 (1.29, 2.77), metabolic syndrome: 1.52 (1.03, 2.25)). Glaucoma prevalence was borderline significantly increased according to the number of metabolic abnormalities(age and sex adjusted p for trend = 0.055). Use of antihypertensive medication was significantly associated with the risk of glaucoma.
Conclusions: Metabolic syndrome and impaired fasting glucose were significantly associated with the increased glaucoma risk. Use of antihypertensive medication was also significantly associated with the increased glaucoma risk.
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KEYWORD
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Metabolic syndrome, Glaucoma, Hypertension, Diabetes mellitus
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